International journal of pharmaceutical sciences and research. Microemulsion me formulation how to develop a microemulsion me formulation microemulsion are, by definition, optically clear dispersion of one physically incompatible liquid into another. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. These are a thermodynamically stable, isotropic liquid mixture of oil, water and surfactant. Emulsion, micro emulsion, nano emulsion, surface tension. Design and evaluation of microemulsion gel system of nadifloxacin. This may be considered as an extension of w insors classification form ing the fifth category. Microemulsions combine the advantages of emulsions with those of nanocarriers. The trend of growing interest in alternative source of energy focuses on renewable products worldwide. Formulation and development of microemulsion and smedds akshay r. Microemulsion is one of the promising submicron carriers for topical drug delivery as it offers advantages like high drugloading capacity and good skin penetration. Characterization of microemulsions prepared using isopropyl. Pharm quality assurance department of pharmaceutics faculty of pharmacy jamia hamdard new delhi 110062 supervisor dr. An me gel base composed of 35% ipm, 20% water, and 45% tween 80.
The external phase was added in a drop wise manner under vortex mixing. Generally the aqueous mixture consists of salt or other substances and the oil part contains hydrocarbons or olefins. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Preparation and evaluation of fluconazole topical microemulsion article pdf available in journal of pharmacy research 23 january 2009 with 1,230 reads how we measure reads. Development and evaluation of a microemulsion formulation for. Optimization, development and evaluation of microemulsion. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. Mandal baroda college of pharmacy, vadodara, india. The microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. Preparation and evaluation of microemulsion formulations of. Nature of oil assessment of the rheological properties 60 increase in the. The process was optimized for the speed and time of stirring using ng microemulsion and results tabulated in table 5. The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for oral use.
Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam biswajit biswal1, nabin karna 1, jyotiranjan nayak2, vivek joshi 1dept. The reversemicelles obtained at a particular ratio of the aqueous phase to the surfactant leads to. We conclude that the formation reactions of these microemulsions studies are entropydriven. The final product developed is a lyophilized amphotericin b, oil and surfactant blend for reconstitution in water to yield a microemulsion containing 5 mgml of the drug. Design and formulation of optimized microemulsions for. Microemulsions me are a novel drug delivery system conventionally composed of oil, surfactant, cosurfactant and aqueous phases 5 and have. Formulation and evaluation of microemulsion based delivery. Formulation and characterization of microemulsion system. Preparation and evaluation of microemulsion systems. The result showed that the microemulsion is a suitable carrier for catechin topical application. Preparation, optimization and characterization of microemulsions 170 titrated with the continuous phase. Microemulsion formulation design and evaluation for. Development and evaluation of a microemulsion formulation for transdermal delivery of diclofenac diethylammonium harsha kathpalia, dr. For other materials, the microemulsion contains all above plus one.
Nimodipine is a calcium channel blocker that has poor oral bioavailability 330% due to its. Formulation and evaluation of microemulsionbased hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Moreover, the microemulsion with and without catechin showed less irritant properties when compared with the standard irritant group. The final concentration of np in the microemulsion system was 100 mgg ww. Formulation and evaluation of microemulsionbased hydrogel. Preparation and evaluation of microemulsionbased transdermal. Faculty of pharmacy, dehradun institute of technology, dehradun, uttarakhand, india. Pg as surfactantcosurfactant mixture scos in ratio of 15.
Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Pseudoternary phase diagrams were constructed using water titration method at 252c to obtain the appropriate components, and their concentration ranges that resulted in a large existence area of microemulsion were chosen. The physicochemical properties such as electrical conductivity, droplet size, viscosity, ph and phase inversion temperature of microemulsions were measured. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. Abstract nanoemulsion ne is defined as an ow or wo emulsion producing a transparent product that has a droplet size from 20200nm and does not have the tendency to coalesce. Interfacial tension, measurement, effect of surfactant on. Preparation and evaluation of microemulsionbased transdermal delivery of total flavone of rhizoma arisaematis lina shen,1 yongtai zhang,1 qin wang,2 ling xu,2 nianping feng11department of pharmaceutical sciences, 2department of oncology, longhua hospital, shanghai university of traditional chinese medicine, shanghai, peoples republic of chinaabstract. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Optimised microemulsion systems were formulated into gel form and evaluated for viscosity, spreadability, drug content, ex vivo skin permeation and antibacterial. The drugloaded microemulsion formulation was stable for at least 3 months of storage at 25 c.
Hydrogel thickened microemulsions were characterized for ph, viscosity, spreadability, in vitro drug transport study with excised rat skins and. Vedha hari department of pharmaceutical technology, scbt, sastra university, thanjavur6401. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. Sep 24, 2014 the trend of growing interest in alternative source of energy focuses on renewable products worldwide. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. Formulation and development of microemulsion and smedds. May 30, 2015 in general ow microemulsion wo reverse microemulsion if the medium is free of oil then aggregates are very small, while the presence of oil makes large surfactant aggregates in general, all microemulsions are made of swollen micelles with oilwater inside them. Formulation and evaluation of microemulsion system for transdermal delivery of nimodipine prashant khade, ganesh chailang, gurauraj shahabade, sujit kakade, sachin kotwal pdeas shankarrao ursal college of pharmaceutical sciences and research center, kharadi, pune14, india. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of. Optimization, development and evaluation of microemulsion for.
For viscosity determination of microemulsion based hydrogel, 175 g of microemulsion based hydrogel was filled in a 250 ml beaker and the viscosity was measured by using spindle number lv4. Topical antiacne microemulsion formulation of essential. B, madhu gudipati, gp bhagath, formulation and evaluation of gastro retentive floating drug delivery system of metoprolol tartarate, international journal of life sciences biotechnology and pharma research, january 20, issn. Microemulsion was first introduced by hoar and schulman in 1943. Microemulsion based gel of voriconazole broadspectrum antifungal agent could be an effective strategy for treatment of topical fungal infections. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Optimization, development and evaluation of microemulsion for the release of combination of guaifenesin and phenylephrine s.
Introduction since from the past years, the oral drug delivery system has been taken to a new extent with the. Interfacial tension, measurement, effect of surfactant on oilwater interface. Formulation and evaluation of lorazepam microemulsion for parenteral delivery system studia universitatis vasile goldis, seria stiintele vietii vol. For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol. A microemulsion forming systems is shown in figure 1.
Soni, rekha mishra institute of pharmacy, bundelkhand university, jhansi, india. Formulation and evaluation of microemulsion based gel of. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34. Microemulsion based gel has been increased interest during recent years in the use of topical vehicle systems that could modify drug permeation through the skin. Formulation and evaluation of lorazepam microemulsion for parenteral delivery system sayani bhattacharyya1,renuka priya vuppalapati1 1dept of pharmaceutics,the oxford college of pharmacy, bangalore, india. For viscosity determination of microemulsionbased hydrogel, 175 g of microemulsionbased hydrogel was filled in a 250 ml beaker and the viscosity was measured by using spindle number lv4.
World journal of pharmaceutical sciences formulation and. Jan 18, 2008 the present studies were designed to develop a formulation of amphotericin b in a lipidbased preparation as a microemulsion and to compare its toxicity with the commercial formulation fungizone. Formulation and evaluation of microemulsion based topical. In short, reverse micelles can be defined as water in oil microemulsion in which polar head groups of surfactant molecules are attracted by aqueous core and directed towards inside and hydrocarbon chain i. Full text preparation and evaluation of microemulsion. Lesser the viscosity, better the administration of the. The objective of this investigation was to develop lorazepam microemulsion without a cosolvent. They may become unstable at low or high temperature but when the temperature returns to the stability range, the micro emulsion reforms. Record the volumes of water v belonging to the emulsion, gel and. Interfacial tension, measurement, effect of surfactant on oil. This system is reckoned advantageous because of its wide applications in colloidal drug delivery systems for the purpose of drug targeting and controlled release the formation of micro emulsion is reversible.
Formulation and evaluation of microemulsion based hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. One of the most promising techniques for enhancement of transdermal permeation of drugs is microemulsion. Formulation and characterization of microemulsion based. Microemulsion research articles omics international. These points combine to form regions with boundaries between them, which. Exploration of safe excipients and evaluation of the toxicity parameters of available excipients may help in further expansion of research in this field. However, the situation of petroleum industries in many countries needs much concern in improving the oil recovery technique. Vandana bhalla patravale, komal sharma abstract the aim of the present study was to prepare and evaluate different formulations of diclofenac. The viscosity of the microemulsion formulations was determined at various 10, 20, 50, 100, 150, 200 rpm operating at 37. Microemulsion is defined as microemulsion are clear, transparent, thermodynamically stable dispersions of oil and water, stabilized by an interfacial film of surfactant. Drugloaded microemulsions were successfully prepared by a water titration method. The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. In this method, adding the oil, surfactant mixture to some of the aqueous phase in a.
Formulation and characterization of microemulsion based gel. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. Microemulsion can be defined as a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution 1. Preparation and evaluation of microemulsion formulations of naproxen for dermal delivery. This paper describes formulation considerations and in vitro evaluation of an oleic acidbased polyelectrolytic polymercontaining microemulsion drug delivery system designed for intranasal administration of a hydrophobic model drug olanzapine. Microemulsions are versatile systems and drug delivery systems that have been. Microemulsions may be defined as oil dispersed in water or water dispersed in oil. Design and formulation of optimized microemulsions for dermal.
The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Formulation and evaluation of microemulsionsbased drug. Development and evaluation of a microemulsion formulation. Preparation and evaluation of microemulsion formulations. Design and development of hydrogel based microemulsion of. Hoar and schulman stimulated the interest of researchers in microemulsions in 1943 when they found that the addition of. Microemulsions have several industrial applications among which the most important is its use in the. Microemulsions are clear, thermodynamically stable, isotropic liquid mixtures of oil, water and. Pdf preparation and evaluation of fluconazole topical. Formulation and evaluation of nanoemulsion of amphotericin b harika k, subhashis debnath, m niranjan babu department of pharmaceutics, seven hills college of pharmacy, venkatramapuram, tirupathi 517561, andhra pradesh, india.
Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its ability to reduce interfacial tension between. Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its ability to reduce interfacial. Pdf formulation and evaluation of microemulsionbased.
Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. Design and development of hydrogel based microemulsion of valacyclovir hydrochloride preeti kamaria, ayushi patwa, anamika saxena, kalpesh gaur, rahul garg, piyush agrawal and ashok dashora geetanjali institute of pharmacy, geetanjali university, udaipur, rajasthan, india. In chapter 1 a short introduction about the background, various aspects and applications. Simultaneous presenceof two microemulsion phases, one in contact with water and the other in contact with oil is also possible. Marry college of pharmacy, secunderabad andhra pradesh, india. Y patil college of pharmacy, akurdi, pune maharashtra, india 2st. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid.
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